Files larger than 50MB will take a considerable amount of time to print or will not print at all, in order to reduce your waiting time and ensure your file prints, please flatten or compress it before sending to printer.
Select a picture in your document, Click on Format and then select Compress Pictures
In the window which appears, make sure you uncheck the box Apply only to this picture if you wish to compress all your pictures in the document. Now choose the target output, if your file size is far too high, try E-mail (96 ppi) as this is the smallest option. Once you have chosen your settings, click OK.
Select a picture in your document, Click on Format and then select Compress Pictures (as per in Word/PPT)
In the window which appears, make sure you check the box Apply to all pictures in the publication if you wish to compress all your pictures in the document.Also make sure all the boxes in Compression options are checked as these will help reduce image sizes. Now choose the target output, if your file size is far too high, try Web as this is the smallest option, the window will show the estimated size of your images after compression, so you can adjust the settings accordingly. Once you have chosen your settings, click Compress.
Go to File > Scripts and select Image Processor
In the first section, choose the image/s you wish to use. Then skip down to the third section, File Type, and in the Quality box, enter your chosen quality number, with 1 being the lowest. Then click on Run and Photoshop will process it for you.
PDF (With Adobe Acrobat):
Go to File > Save As and select Optimized PDF…
The PDF Optimizer window will appear. Before you start, you might want to click on the Audit space usage… button to see what parts of your PDF are taking up the most of your file size.
You can then adjust the settings by navigating around the Optimizer window. You will most likely need to reduce the quality of the images. Once you are happy with your settings, click on OK and you will be brought to the normal save screen.
PDF (With Adobe Reader):
Go to File > Print
In the Printer: drop down, select Adobe PDF and then click on Properties
Make sure you are in the Adobe PDF Settings tab, then in the Default Settings drop down, select Smallest File Size, then click on OK
Now click on Print. This will create a new PDF (a window will appear asking you to Save, do this as you would any normal document) which should be reduced in file size.
Go to File > Save As…
In the Save as type: drop down, select Adobe PDF, then click on Save
Uncheck the boxes for Preserve Illustrator Editing Capabilities and Create Acrobat Layers from Top-Level Layers and then check the box for Optimize for Fast Web View. This will reduce the file size to near minimum, you can also go to the Compression tab and chose to sample the images.
If you wish to do this remember that the smaller the ppi the smaller the file size will be.